In modern biomedical research that is being realized in CIID, microscopy-based experimental approach has a central role. A comprehensive understanding of host-pathogen interactions requires quantitative assessment of molecular events across a wide range of spatiotemporal scales and organizational complexities Due to recent technical developments, this is currently only achievable with microscopy. Based on development of new imaging modalities, fluorescent probes and sensors, computer technology, image analysis algorithms and new biological model system, the field of biological microscopy is undergoing a revolution. Only now we are starting to appreciate and make use of the full potential of the microscopy-based experimental approach. Modern microscopes have evolved into complex robotic instruments capable of automatically interrogating a wide range of biological processes at vastly different spatiotemporal scales and organizational complexities, from structural studies on macromolecular scale all the way to whole organ/body imaging in living animals.
We believe that modern microscopy technology is currently uniquely positioned to propel the infectious disease research to a new frontier. For these reasons, we are establishing and applying advanced microscopy infrastructure to allow infectious disease research across the range of different spatiotemporal scales and organizational complexities.