2 | Innate sensing and restriction of HIV‑1
The innate immune system is increasingly recognized as a major arm of immunity against efficient HIV‑1 replication that poses cell-intrinsic barriers to virus replication (restriction factors) and elicits antiviral signaling upon recognition of replication intermediates (by sensors). Our current work focusses on two aspects of innate immune defenses against HIV.
a) Host cell restriction by SERINC proteins
SERINC3 and 5 were recently identified as host cell restriction factors that potently suppress the infectivity of HIV‑1 virions. This antiviral activity can be counteracted by the HIV‑1 protein Nef. We are studying the mechanisms underlying the antiviral action of SERINC proteins as well as its antagonism by Nef.