Research projects in our group address different aspects of retroviral and influenza virus (IAV) biology. A long-term interest of the group is the formation and architecture of the infectious human immunodeficiency virus (HIV) particle. A major current focus in the lab is the study of entry and post-entry stages in the life cycle of HIV‑1 and murine leukemia virus and the role of innate immune responses in these processes. We combine conventional and super-resolution microscopy as well as correlative-light and electron microscopy (CLEM) to study the composition and architecture of entering subviral complexes and the interaction with cellular proteins and structures. Other projects address the role of lipids for virus assembly and cell entry, the use of CRISP/Cas based approaches for HIV‑1 elimination, and the spread of influenza virus in complex cell systems.
Our main Research Interests are :