Research projects in our group address dif­fer­ent aspects of retro­vi­ral and influen­za virus (IAV) biol­o­gy. A long-term inter­est of the group is the for­ma­tion and archi­tec­ture of the infec­tious human immun­od­e­fi­cien­cy virus (HIV) par­ti­cle. A major cur­rent focus in the lab is the study of  entry and post-entry stages in the life cycle of HIV‑1 and murine leukemia virus and the role of innate immune respons­es in these process­es. We com­bine con­ven­tion­al and super-res­o­lu­tion microscopy as well as cor­rel­a­tive-light and elec­tron microscopy (CLEM) to study the com­po­si­tion and archi­tec­ture of enter­ing sub­vi­ral com­plex­es and the inter­ac­tion with cel­lu­lar pro­teins and struc­tures. Oth­er projects address the role of lipids for virus assem­bly and cell entry, the use of CRISP/Cas based approach­es for HIV‑1 elim­i­na­tion, and the spread of influen­za virus in com­plex cell systems.

Our main Research Inter­ests are :

For more infor­ma­tion please visit:

https://www.klinikum.uni-heidelberg.de/zentrum-fuer-infektiologie/virologie/forschung/forschungsgruppen/kraeusslich/