Prof. Dr. med Hans-Georg Kräus­slich

Hans-Georg.Kraeusslich@med.uni-heidelberg.de

Phone: ++49-(0)6221–56-5001

Fax: ++49-(0)6221–56-5003

Retroviral and Influenza Virus (IAV) Biology

Projects

Research projects in our group address dif­fer­ent aspects of retro­vi­ral and influen­za virus (IAV) biol­o­gy. A long-term inter­est of the group is the for­ma­tion and archi­tec­ture of the infec­tious human immun­od­e­fi­cien­cy virus (HIV) par­ti­cle. A major cur­rent focus in the lab is the study of  entry and post-entry stages in the life cycle of HIV‑1 and murine leukemia virus and the role of innate immune respons­es in these process­es. We com­bine con­ven­tion­al and super-res­o­lu­tion microscopy as well as cor­rel­a­tive-light and elec­tron microscopy (CLEM) to study the com­po­si­tion and archi­tec­ture of enter­ing sub­vi­ral com­plex­es and the inter­ac­tion with cel­lu­lar pro­teins and struc­tures. Oth­er projects address the role of lipids for virus assem­bly and cell entry, the use of CRISP/Cas based approach­es for HIV‑1 elim­i­na­tion, and the spread of influen­za virus in com­plex cell sys­tems.

Our main Research Inter­ests are :

  • Mor­pho­gen­e­sis and struc­ture of HIV

  • Post-entry stages in retro­vi­ral repli­ca­tion

  • Role of lipids in virus repli­ca­tion

  • Influen­za virus entry and spread in com­plex tis­sues

  • CRISP/Cas based approach­es for HIV‑1 elim­i­na­tion