Our orig­i­nal inter­ests focused on the mol­e­c­u­lar virol­o­gy of HCV, includ­ing the devel­op­ment of robust cell cul­ture mod­els and their use to study the viral repli­ca­tion cycle. In the last few years, we put an empha­sis on virus – host cell inter­ac­tion by using nov­el imag­ing meth­ods and high res­o­lu­tion microscopy. More­over, we are active­ly work­ing on innate immune respons­es induced by infec­tions and viral coun­ter­mea­sures. Final­ly, we inte­grat­ed sys­tems biol­o­gy approach­es in com­bi­na­tion with math­e­mat­i­cal mod­el­ing of bio­log­i­cal process­es. By includ­ing the fla­vivirus­es into our research port­fo­lio, we are able to com­pare how a per­sis­tent (HCV) and an acute lyt­ic virus (e.g. Dengue virus) deal with the host cell.

For a descrip­tion of our research projects please fol­low the link below:
https://www.klinikum.uni-heidelberg.de/zentrum-fuer-infektiologie/molecular-virology/
about-us/re­search-team­s/ag-barten­schlager